We are thrilled to unveil our latest triumph in the realm of scientific inquiry: the cover feature of the Journal of Immunology. Led by one of our eminent Pitt Infectious Diseases research teams, the publication, “Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-term Antiretroviral Therapy,” marks a significant advancement in our understanding of HIV-1 pathogenesis and immune response dynamics.

This seminal work, meticulously conducted in collaboration with the Rustbelt CFAR Core F technology, sheds light on the intricate interplay between HIV-1 infection and the immune system. Through rigorous analysis, we have discerned a skewed repertoire of natural killer (NK) cells persisting in individuals undergoing long-term antiretroviral therapy. Notably, the findings illuminate the interruption of NK-poiesis, as evidenced by inflated proportions of NK cells expressing genes associated with ‘young’ and ‘intermediate’ stages of differentiation.

The cover image, a captivating heatmap captured by Renee Anderko and Allison DePuyt, visually encapsulates the essence of our research. It vividly portrays the unique single-cell transcriptional patterns of four distinct subsets of NK cells observed in individuals with HIV-1, offering a glimpse into the complexities of immune dysregulation in this population.

Featured prominently under the Innate Immunity and Inflammation category in this month’s issue (Volume 212, Issue 10), this article stands as a testament to the relentless pursuit of scientific excellence embodied by our team. We extend our heartfelt gratitude to all collaborators and supporters who have contributed to this endeavor. Join us in celebrating this momentous achievement and anticipate further groundbreaking discoveries as we continue to unravel the mysteries of infectious diseases and immunology.

https://journals.aai.org/jimmunol/article-abstract/212/10/1564/266792/Persistence-of-a-Skewed-Repertoire-of-NK-Cells-in?redirectedFrom=fulltext